A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network
نویسندگان
چکیده
منابع مشابه
A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network
There was an error published in J. Cell Sci. 126, 1454-1463. Equal contributions of the two last authors should have been indicated in the Author contributions section. The complete Author contributions section is given below. Author contributions L.K.N., M.A.S.C., C.C.S., S.F.F., U.B., E.P.C., M.M.T., M.C.M. and A.C. performed the experiments; L.K.N., M.A.S.C. and A.C. analyzed the results and...
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Hypoxia occurs in solid tumours due to a mismatch between tumour growth and angiogenesis. Hypoxia in solid tumours is associated with an aggressive phenotype and resistance to radiation therapy and chemotherapy leading to poor patient prognosis. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor, which is activated in response to intratumoural hypoxia and as a result of genetic altera...
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RESEARCHDESIGNANDMETHODSdIn 1,165 American type 1 diabetic patients with and without DN selected from the Genetics of Kidneys in Diabetes (GoKinD) study, the HIF1A genetic polymorphisms were genotyped with TaqMan allelic discrimination. The regulation of HIF1a in the kidneys of diabetic mice was appreciated by immunohistochemistry, and the effectHIF1A Pro582Ser polymorphism on HIF-1a sensitivit...
متن کاملA dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network.
Activation of the hypoxia-inducible factor (HIF) pathway is a critical step in the transcriptional response to hypoxia. Although many of the key proteins involved have been characterised, the dynamics of their interactions in generating this response remain unclear. In the present study, we have generated a comprehensive mathematical model of the HIF-1α pathway based on core validated component...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2015
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.167304